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Close-up of a sagittal section showing very large (some with a diameter larger than 5 cm) leiomyomas, or uterine fibroids, in a human uterus that has been removed (hysterectomy). These are fibrous benign tumours originating from uterine smooth muscle that may lead to excessive menstrual bleeding, pain, and other disorders. At centre is the narrow uterine lumen. (KEYSTONE/SCIENCE PHOTO LIBRARY/JOSE CALVO / SCIENCE PHOTO LIBRARY)