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FILE - In this Sept. 27, 2010 file photo, American actor George Clooney holds hands with his girlfriend Elisabetta Canalis prior to the presentation of the Armani Spring-Summer 2011 fashion collection, during the fashion week in Milan, Italy. George Clooney's highly anticipated new movie about a U.S. presidential campaign will open this year's Venice Film Festival, organizers said Wednesday, June 22, 2011. But news about the world premiere of the American actor's latest directorial effort was likely to be overshadowed Wednesday by the news that Clooney and his Italian girlfriend had split up. "We are not together anymore,'' said a joint statement by Clooney and Elisabetta Canalis. "It's very difficult and very personal and we hope everyone can respect our privacy.'' (AP Photo/Luca Bruno)