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AREIAS, PARAIBA STATE, BRAZIL. 19/10/2016. Marcela, 2 years-old, observes her twin sisters Heloá (right) and Heloisa (left), , seven months old, both with microcephaly caused by the Zika virus, in her mother's lap at the family's home in the rural area of Areias..The state of Paraíba, located in the Northeast region of Brazil, has one of the highest rates of microcephaly caused by the Zika virus in the country. (Lalo de Almeida, for Folha de Sao Paulo) NO SALES, THIS MATERIAL IS FOR SINGLE USE PUBLICATIONS IN PRINT OR FOR A TEMPORARY ONLINE PUBLICATION, AND MAY BE USED EXCLUSIVELY TO PUBLICIZE THE 2017 WORLD PRESS CONTEST AND EXHIBITION. IT MAY NOT BE PUBLISHED AS PART OF AN ARTICLE OR ANY OTHER ITEM THAT CONTAINS NO DIRECT LINK TO WORLD PRESS PHOTO AND ITS ACTIVITIES. THE PICTURE MAY NOT BE CROPPED OR MANIPULATED IN ANY WAY. KEYSTONE PROVIDES ACCESS TO THIS PUBLICLY DISTRIBUTED HANDOUT PHOTO. THE COPYRIGHT IS OWNED BY A THIRD PARTY.